Pharmacy

| Department Overview |--------------

The Department of Pharmacy is a first-class discipline in Shanghai. In 2016, ranking first, it was among the first batch to be awarded the Shanghai Municipal Health Commission's "Key Clinical Pharmacy Specialty" designation and, with a significant advantage, was selected for Shanghai Municipality's "Takeoff Plan", receiving the joint development project for a weak discipline (Clinical Pharmacy). The Department of Pharmacy is an affiliated institution of the Shanghai Clinical Pharmaceutical Affairs Management Quality Control Center and the Shanghai Clinical Adverse Drug Reaction Monitoring Center, and has repeatedly received such titles as Shanghai Excellent Unit for Clinical Pharmaceutical Affairs Quality Control and National Excellent Unit for Adverse Reaction Monitoring. In 2023, it was selected as one of the first batch of national pilot units for the work model of pharmacists stationed in clinical departments and as a training-base unit for urgently needed talent (clinical pharmacists).

Since the hospital was founded and the department was established in 1907, colleagues of successive generations have worked hard and forged ahead. The Department of Pharmacy has become a discipline team with a well-developed organizational structure, a sound talent pipeline, an international perspective, a commitment to innovation, and openness and inclusiveness, as well as a comprehensive pharmaceutical department integrating medical care, teaching, and research. The Department of Pharmacy has an outstanding talent team, with 168 pharmaceutical professional and technical personnel, including 7 chief pharmacists, 10 deputy chief pharmacists, 22 doctoral degree holders, and 23 master's degree holders; personnel with bachelor's degrees or above account for 80%, and many have gone to the United States, Canada, and elsewhere for further study. It currently has 1 National Distinguished Young Scholar (dual appointment). Department members serve as committee members and young leaders of various study groups at the national and Shanghai municipal levels, and the Department of Pharmacy currently serves as the chairperson/vice-chairperson unit of the Chinese Pharmaceutical Association, the Chinese Pharmacological Society, the Shanghai Pharmaceutical Association, and the Shanghai Hospital Association.

Hospital pharmacy services first meet clinical needs and ensure the growing supply of medicines. The drug supply department comprises 3 drug warehouses, 27 pharmacies, 1 preparation room, 1 drug inspection room, and 3 centralized intravenous drug compounding centers; it is also equipped with fully automated dispensing machines, a unit-dose packaging system, an intelligent management system for narcotic and psychotropic drugs, an automated dispensing machine for the emergency pharmacy, and so on, comprehensively ensuring drug quality and routine supply. In 2024, a demonstrative smart pharmacy for clinical research was completed, realizing centralized management and full-process traceability for the drugs used in more than 200 clinical research projects.

Huashan Hospital's preparation room was among the first units in Shanghai to obtain certification under the "Quality Specification for Medical Institution Preparation Rooms", and obtained a "Medical Institution Preparation Production License". The hospital's preparations have fully explored and carried forward the distinctive features and advantages of clinical medication at our hospital, effectively meeting the clinical medication needs of some patients, and are an important component of the hospital's medicines. The self-manufactured preparations with brand impact were developed through the joint efforts of pharmacy pioneers and medical experts; they are distinctive products adapted to clinical needs, safe and effective, and available in numerous varieties, and have long been trusted by clinicians and patients. Among them, Urea Cream, Suomixin Urea Cream, Compound Clindamycin Gel (Kangzhi Jier), Cream Base No. 1 (6101 Cream), Allantoin Vitamin E Cream (Fugui Cream), Lübo Disong Liniment (Fudi Liniment), Dexamethasone Acetate Liniment (Dibing Liniment), as well as Ammonium Chloride and Liquorice Oral Solution, Qibai Granules, Shenqi Shengji Granules, Lidan Granules, Shenwu Oral Solution, and Lishi Oral Solution, are widely acclaimed in clinical use in dermatology, neurology, traditional Chinese medicine, general surgery, and other departments. Over the past 6 years, following annual sampling inspections by the Shanghai Municipal Drug Administration and unannounced inspections by the Inspection Bureau, the quality results have all been quite satisfactory. Through the continued efforts of the new-generation preparation production and drug inspection teams, the annual output value of Huashan preparations has risen in parallel with the growth in the hospital's medical scale. While ensuring clinical supply, the team strives to refine and improve the preparation brand, while also focusing on the development and translation of new preparations, so that preparation production can enter the fast lane and preparation development can embark on a new journey. Because of its outstanding achievements in attaining both quality and output gains while ensuring safe production, the team received an official commendation from the Shanghai Municipal Committee of the Communist Youth League for its Youth Work Safety Post at the beginning of 2024.

Pharmacist Team of the Preparation and Drug Inspection Rooms

Academic Leader:

Former department directors were Wang Guofen, Zhang Jinghua, Zhang Lili, and Zhong Mingkang; the current department director is Wang Bin.

Wang Bin, Chief Pharmacist and doctoral supervisor, is Director of the Department of Pharmacy of Huashan Hospital, Fudan University. Wang Bin is Chair of the Pharmacoepidemiology Professional Committee of the Shanghai Pharmaceutical Association, an executive council member of the Shanghai Pharmaceutical Association, Vice Chair of the Clinical Pharmaceutical Affairs Professional Committee of the Shanghai Hospital Association, an expert on the Medical Accident Appraisal Committee of the Chinese Medical Association, and Vice Chair of the Regional Pharmaceutical Care Promotion Association of the Chinese Pharmacist Association. Wang Bin undertakes General Program projects of the National Natural Science Foundation of China, projects of the Ministry of Science and Technology and the Municipal Science and Technology Commission, among others. Ranking first, Wang Bin received: the Shanghai Outstanding Invention and Innovation Silver Award, the "Outstanding Achievement Award" of the Shanghai Pharmaceutical Science and Technology Award, the Chinese Pharmaceutical Association Science and Technology Third Prize, and the Chinese Pharmaceutical Association Outstanding Pharmacist award.

| Clinical Specialty Features and Projects Conducted |--------------

Clinical Pharmacy

Huashan Hospital is one of the earliest hospitals to undertake clinical pharmacy work and was also among the first teaching hospitals to offer a clinical pharmacy master's program.

Our hospital has strong clinical service and research capabilities in monitoring and evaluating the rational use of clinical medicines, adverse drug event management, clinical pharmaceutical care for inpatients, chronic disease management, pharmacy clinics, management of the clinical use of antimicrobial drugs, and individualized dosing regimen design. As an affiliated institution of the Shanghai Clinical Adverse Drug Reaction Monitoring Center, our hospital's adverse drug reaction management work has consistently been at the forefront of Shanghai and even the country. It is a member unit of the National Adverse Drug Reaction Monitoring Sentinel Alliance and a National Excellent Unit for Adverse Drug Reaction Monitoring.

In 2010, our hospital became a clinical pharmacist training base of the Health Commission, and in 2024 it became one of the first batch of national pilot units designated by the National Health Commission for the work model of pharmacists stationed in clinical departments. Clinical pharmacy work currently covers the Department of Infectious Diseases, Department of Neurology, Department of Nephrology, Department of General Surgery, Department of Rheumatology, Department of Oncology, Department of Hematology, Department of Cardiology, Department of Orthopedics, ICU, and other clinical departments; it has established 5 specialty clinical pharmacist training bases: immunological drugs, neurology, anti-infective drugs, anticoagulant drugs, and antineoplastic drugs. As early as the beginning of 2000, it established a joint medical-pharmaceutical outpatient clinic, and in 2018 it established independent online and offline pharmacy clinics. A regularized and standardized pharmaceutical care model for inpatients and outpatients has been established, along with a series of advanced intelligent information management systems, including the Clinical Pharmacist Workstation, the full-process adverse drug reaction management system, the patient ADR reporting and handling system, the antimicrobial drug AI management platform, the individualized treatment clinical decision system, and the comprehensive drug evaluation platform.

Drug Concentration Testing and Pharmacogenetic Testing

In recent years, the Department of Pharmacy has focused on developing the "Drug-Related Gene Testing Laboratory" and the "Therapeutic Drug Monitoring Laboratory", conducting more than 40 pharmacogenomics (PGx) and therapeutic drug monitoring (TDM) projects, and participating in Phase I clinical research on a national Class I new drug. These innovative services serve approximately 4,000 patient visits each year, effectively improving the safety, efficacy, and rationality of clinical medication. They have played a positive demonstrative and leading role in promoting the in-depth development of clinical pharmacy and have provided reference and experience for innovation in pharmaceutical service models.

Clinical Pharmacist Team

Clinical Pharmacist Team of the Pharmacy Clinics

| Teaching |--------------

In 1999, the Hospital Pharmacy Teaching and Research Office of Shanghai Medical University was affiliated with the Department of Pharmacy of Huashan Hospital (Zhang Lili and Zhong Mingkang successively served as directors of the teaching and research office); in 2012, the teaching and research office was incorporated into the Fudan University School of Pharmacy. In 2004, it became a doctoral enrollment site for the clinical pharmacy specialty, and in 2007 the Huashan Department of Pharmacy and the Department of Pharmaceutics of the Fudan University School of Pharmacy jointly successfully applied to become a key discipline under the Ministry of Education's "985" program. There are currently 5 doctoral supervisors and 9 master's supervisors; the department undertakes teaching and intern supervision for courses including "Pharmacotherapy", "Clinical Pharmacy Practice and Skills", and "Pharmacogenomics" at the Fudan University School of Pharmacy.

In 2010, the clinical pharmacy department of the Department of Pharmacy became a clinical pharmacist training base of the Ministry of Health (now the Health Commission). It currently has five specialty tracks: anti-infective drugs, neurology, nephrology, anticoagulation, and oncology. Each year, it admits 18-20 advanced-study trainees and, as one of the first batch of Shanghai clinical pharmacist training bases, trains 6-8 Shanghai trainees each year.

Each year, the department holds multiple national and provincial/ministerial continuing education courses and the Huashan Pharmacist Forum. Since 2012, it has periodically invited domestic and international experts to hold international academic exchange conferences, exchanged visits with clinical pharmacy scholars from the University of Illinois and elsewhere, and become a clinical pharmacy practice base of University at Albany.

Over the years, the department has emphasized talent development. One person was selected for the Shanghai Municipal Health Bureau's "Hundred Talents Plan", 8 people were selected for the Shanghai Medical Garden New Star Young Medical Talent (Clinical Pharmacist) Training Plan, and 3 people were selected for the Shanghai Municipal Science and Technology Commission's Young Scientific and Technological Talents "Sail Plan". Many have been selected as "Pharmacy Elites" of the Shanghai Medical Association, Outstanding Clinical Pharmacists of the Shanghai Medical Association, among the Top Ten Medical Youth of Fudan University, and for the "Huaxiu Award" of Huashan Hospital, among others.

| Research |--------------

In research innovation in hospital pharmacy, the department's platform develops technologies for therapeutic drug monitoring, drug-related gene testing, and individualized dosing design; conducts research on the changes drugs undergo in the human body and their mechanisms of action; and uses data-analysis technologies for monitoring clinical drug use and clinical adverse drug events to evaluate the rationality of clinical drug use and drug safety. It actively conducts patient-centered clinical pharmacy practice, focusing on clinical monitoring and comprehensive evaluation of antimicrobial drugs, antiepileptic drugs, antineoplastic drugs, and anti-rejection drugs, thereby improving the service capacity of clinical pharmacy and achieving significant results.

The Department of Pharmacy has further expanded its subdisciplinary specialties, mainly including: 1) clinical-problem-oriented multi-omics research and translation; 2) quantitative pharmacology, therapeutic drug monitoring, and individualized dosing research; 3) pharmacological research on immuno-oncology drugs; 4) neuropharmacology and antibiotic pharmacology research; 5) pharmacoepidemiology and pharmacovigilance research; 6) artificial-intelligence-based construction of disease prognosis and risk models and precision pharmaceutical services, among others.

From 2017-2024, the department received approval for 15 National Natural Science Foundation of China projects and more than 10 other projects, including general and young investigator projects of the Municipal Science and Technology Commission, projects of the Municipal Health Commission, and the Shanghai Sail Plan. More than 100 articles were published as first and corresponding author in foreign SCI-indexed journals such as Nature communications and J Control Release, and dozens of national invention patents were applied for. Department members received Shanghai Outstanding Invention Gold and Silver Awards, the Shanghai Medical Science and Technology Award Third Prize, and the Chinese Pharmaceutical Association Science and Technology Award Third Prize.

| Department Honors |--------------

2024 National Health Commission "9th National Hospital Challenge Competition for Improving Medical Services" Bronze Award

2024 8th Season China Hospital Management Award, Pharmacy Management Theme, Regional Excellence Award

2022 National Health Commission "7th National Hospital Challenge Competition for Improving Medical Services" Excellence in Improving Rational Drug Use Management

Case

2022 Shanghai Medical Science and Technology Award Third Prize

2022 Chinese Pharmaceutical Association "Science and Technology Award Third Prize"

2021 National Health Commission "Promoting Rational Drug Use—Discipline Team"

2020 National Excellent Unit for Adverse Drug Reaction Monitoring

2019 "Rational Drug Use · China Action" Medical Team Practice Award (Medical Administration and Hospital Administration Bureau of the National Health Commission, Health News)

Shanghai Outstanding Invention Gold and Silver Awards

2017-2023 Shanghai Excellent Unit for Clinical Pharmaceutical Affairs Management Quality Control

2021-2023 Shanghai Excellent Clinical Pharmacist Training Base