Reproductive Immunology

The Department of Reproductive Immunology of Shanghai First Maternity and Infant Health Hospital was established in August 2015. It comprises outpatient services, ultrasonography, and laboratory diagnostics, and is a young team integrating medical care, teaching, research, and internet-based healthcare. It currently has 10 clinicians, 1 ultrasonography physician, 2 laboratory technicians, and a total of 5 nurses and clerical staff. Fifty percent of the physicians hold senior professional titles (2 with the highest-level senior titles who also serve as postgraduate supervisors, 3 with associate senior titles, and 5 attending physicians), and 100% have postgraduate degrees (5 doctors and 5 masters).

The Department of Reproductive Immunology is committed to the standardized diagnosis and treatment of reproductive immunological and reproductive endocrine diseases. Its main scope of diagnosis and treatment includes recurrent miscarriage, embryo transfer failure, biochemical pregnancy, infertility, polycystic ovary syndrome, ovarian insufficiency, menstrual disorders, abnormal uterine bleeding, amenorrhea, hyperprolactinemia, and other gynecological endocrine diseases, as well as comprehensive perinatal management of female patients with autoimmune diseases such as antiphospholipid syndrome, Sjögren syndrome, and undifferentiated connective tissue disease. The department has innovatively implemented strategies including tiered diagnosis and treatment, systematic etiological screening, and individualized medication. Patient satisfaction and clinical pregnancy success rates have repeatedly reached new highs. It currently handles more than 100,000 outpatient visits annually, receives many difficult and complex cases, and more than 60% of its patients come from outside Shanghai, making it one of the largest recurrent miscarriage diagnosis and treatment centers in China and internationally.

The Department of Reproductive Immunology is a pioneer in internet-based healthcare at our hospital. In the "2022 China Hospital Internet Influence Ranking" jointly released by the Health Industry Development Research Center of the Chinese Academy of Social Sciences and Haodf.com, the department ranked No. 1 among reproductive medicine specialties, and 4 of its physicians received the title of "Haodf Physician of the Year." The department actively promotes health education in various forms, and 3 physicians were included among the top 100 in the "2023 Shanghai Healthcare Institutions and Healthcare Professionals Health Science Popularization Influence Ranking."

The Department of Reproductive Immunology places particular emphasis on the mutual advancement and integration of clinical and basic medicine. Focusing on the establishment of an immune-tolerant microenvironment at the maternal-fetal interface and research into the pathogenesis of recurrent miscarriage, it has successively received funding from the National Natural Science Foundation of China General Program and Young Scientists Fund, the Shanghai Natural Science Foundation, the Shanghai Municipal Hospitals Joint Research Project on Emerging and Frontier Technologies, and Shanghai municipal medical guidance science and technology projects. It has published more than 50 SCI-indexed papers, served as chief editor, contributing editor, or translator for 7 monographs, and applied for 4 national invention patents, 2 of which have been granted and successfully transferred. For 8 consecutive years, it has successfully hosted the national continuing education program "Recurrent Pregnancy Failure and Female Reproductive Immunology," participated in the development of 6 Chinese expert consensuses related to recurrent miscarriage, received more than 100 visiting physicians from across China for further training, and actively promoted standardized diagnosis and treatment of recurrent miscarriage.