Pediatric Hematology and Endocrinology Ward (Central Campus)

Shandong Provincial Hospital’s Department of Pediatric Hematology and Endocrinology was established in the early 1970s. It is a leading institution in Shandong Province for the diagnosis and treatment of pediatric hematologic and oncologic system diseases and pediatric endocrine system diseases; a major member of the national collaborative groups for pediatric hematologic oncology and endocrine diseases; one of the first-batch designated treatment institutions for children with hematologic tumors under the National Health Commission; a member institution of the Hematologic Oncology Alliance of the National Children’s Medical Center; the chairing institution of the Shandong Children’s Hematology and Endocrinology Alliance; the chairing institution of the Shandong Children’s Bone Marrow Failure Alliance; the chairing institution of the Shandong Children’s Lymphoma Alliance; and the chairing institution of the Specialized Committee of Pediatric Hematologic Oncology of the Shandong Maternal and Child Health Association.

At present, department personnel hold a total of 42 concurrent positions in provincial-level and higher academic societies, associations, and similar organizations, including 17 national-level positions: 4 standing committee members, 1 deputy group leader, and 12 committee members; and 25 provincial-level positions, including 2 chairpersons and 9 deputy chairpersons. They serve on the editorial boards of the Chinese Journal of Pediatrics, Chinese Journal of Pediatric Hematology and Oncology, International Journal of Pediatrics, Shandong Medical Journal, and other journals.

The department is a member institution of 10 national collaborative groups, including the Chinese Pediatric Acute Lymphoblastic Leukemia Collaborative Group, Chinese Pediatric Acute Myeloid Leukemia Collaborative Group, Chinese Pediatric Acute Promyelocytic Leukemia Collaborative Group, Chinese Pediatric Lymphoma Collaborative Group, Chinese Pediatric Neuroblastoma Collaborative Group, Chinese Pediatric Hepatoblastoma Collaborative Group, Chinese Pediatric Bleeding and Coagulation Collaborative Group, Chinese Pediatric Hemophagocytic Syndrome Collaborative Group, Chinese Pediatric Nephroblastoma Collaborative Group, and Chinese Pediatric Bone Marrow Failure Disease Collaborative Group. It is also one of the first-batch provincial designated treatment institutions for children with leukemia and solid tumors under the National Health Commission, the leading treatment institution for children with leukemia and solid tumors in Shandong Province, and an outstanding monitoring institution in nationwide pediatric hematologic oncology surveillance.

Personnel Composition

The department currently has 31 medical and nursing personnel, including 13 physicians, 7 with doctoral degrees and 4 with master’s degrees; comprising 5 chief physicians, 5 deputy chief physicians, and 3 attending physicians; and 19 nurses, including 1 associate chief nurse. Department physicians and nurses have successively undertaken further training and study at the University of Rochester Medical Center in the United States, Prince of Wales Hospital in Hong Kong, Guangdong Zhujiang Hospital, Beijing Children’s Hospital, Shanghai Children’s Medical Center, Tianjin Institute of Hematology, Peking University People’s Hospital, and other institutions, and have a high level of expertise in the diagnosis and treatment of pediatric hematologic, oncologic, and endocrine diseases.

Bed Capacity

The department currently has 48 beds, 10 laminar-flow rooms, 28 ordinary beds, 18 laminar-flow chemotherapy beds, and 1 basic laminar-flow room; each year, it records nearly 2,400 inpatient discharges, more than 2,500 bone marrow aspirations, lumbar punctures, and intrathecal injections, and nearly 30,000 outpatient visits.

Scope of Diagnosis and Treatment

The main diseases treated include pediatric anemic diseases, such as aplastic anemia, hemolytic anemia, and nutritional anemia; pediatric bleeding diseases, such as thrombocytopenic purpura, hemophilia, and coagulation disorders; pediatric neoplastic diseases, such as leukemia, lymphoma, neuroblastoma, nephroblastoma, hepatoblastoma, osteosarcoma, germ-cell tumors, and medulloblastoma; pediatric histiocytic proliferative diseases, such as Langerhans cell histiocytosis and hemophagocytic syndrome; and endocrine diseases, such as diabetes mellitus, diabetes insipidus, short stature, disorders of sexual development, thyroid dysfunction, and adrenal dysfunction. The department also treats difficult and complex conditions, including fever of unknown origin, unexplained weight loss, lymphadenopathy, hepatosplenomegaly, and unexplained bleeding in children, as well as rare diseases, including Gaucher disease and Niemann–Pick disease.

Leading Technologies

MICMS classification and diagnostic technology and MRD monitoring technology; pediatric hematopoietic stem-cell transplantation; treatment of aplastic anemia with immunosuppressants combined with TPO-RA; minimally invasive pediatric bone-marrow aspiration needles; placement and maintenance of venous infusion ports and PICCs; painless procedural technology; immunotherapy and targeted therapy; application of PET-CT technology in stratified diagnosis and prognostic assessment of solid tumors; application of pegaspargase in childhood leukemia; application of insulin pumps and 3C technology; use of the SD-LCH regimen to treat pediatric Langerhans cell histiocytosis; oral arsenic therapy for acute promyelocytic leukemia; and immunotherapy with blinatumomab combined with chemotherapy for children with refractory or relapsed acute lymphoblastic leukemia. Zavesca (miglustat) is used to treat children with Niemann–Pick disease type C, and a dried blood spot enzymatic assay is used to screen children for Gaucher disease. These achievements are the first of their kind in Shandong and are nationally leading.

Research Achievements

In recent years, physicians at all levels have undertaken more than 10 projects related to pediatric hematologic and endocrine systems; the department has received the Shandong Provincial Science and Technology Progress Award 3 times; published more than 100 papers in core journals; and served as chief editor of 12 books. It has led 2 National Natural Science Foundation of China Young Scientists Fund projects, 5 provincial natural science foundation projects, and 2 provincial youth fund projects.

Teaching

Every year, our department undertakes theoretical teaching, internships, and clinical observation assignments for five-year undergraduate students, seven-year master’s students, and international students of the School of Medicine of Shandong University, as well as for graduate and undergraduate students majoring in pediatric hematology and endocrinology at Shandong First Medical University. More than 20 graduate students have been trained.

Honors and Awards

The department has successively been named a “Top Ten Medical Quality Demonstration Department in Shandong Province” and a “Top Ten Brand Department.” It has repeatedly received awards including the “Advanced Award for Comprehensive Target Management,” “New Technology Award,” “Medical Safety Award,” “Advanced Teaching Award,” and “Excellent Medical Record Award,” among others, and has received the honorary title of “Third Most Beautiful Provincial Health Guardian.” In 2018, it received the Silver Award in the First National Health Commission Youth Volunteer Service Competition and the Silver Award in the Third National Youth Volunteer Service Competition. In 2019, it received the “Best Creativity Award” in the national selection of the Second Children’s Hematology Clinical Nutrition Practice Style Exchange Competition and the “Caring Doctor” title in the Bethune Public Welfare Foundation China Hematology Public Welfare Tour. In 2022, it received the titles of “Caring Science-Popularization Expert” from the China Charities Aid Foundation for Children and “Caring Expert” from the Growth Angel Fund of the Chinese Red Cross Foundation.

The department has successively established the “Shandong Province Home for Children with Leukemia,” “Children’s Hemophilia Home,” “Little Angel Fund,” “Shandong Life Little Warriors Association,” “Shandong Life Little Warriors Parents’ Association,” “Shenhua Caring Action,” “New Sunshine Caring Ward Classroom,” and “Shandong Children’s Palliative Care Center.” It has also carried out numerous public-welfare activities and regularly organized doctor–patient exchange meetings and social gatherings. It has assisted more than 500 impoverished children with hematologic malignancies, with cumulative funding approaching 10 million yuan. It has been featured repeatedly in special reports by CCTV, Shandong Television, Dazhong Daily, Qilu Evening News, and numerous other media outlets and online platforms.

Over the years, through the joint efforts of several generations of pediatric hematology and endocrinology staff, the department has developed a distinctive departmental culture: the departmental philosophy of “moral integrity, pursuit of excellence, rigor, and benevolence”; the departmental mission of “putting children at the center, taking quality as the foundation, safety as the guarantee, and responsibility as the cornerstone”; and the departmental spirit of “dedication, teamwork, and a sense of ownership.” The people of pediatric hematology and endocrinology at Shandong Provincial Hospital will continue to strive and advance even further from a strong foundation!